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重組人GM-CSF
Recombinant Human GM-CSF
產品編號: HZ-1051
規  格:
單  價: 詢價
生 產 商: Humanzyme
到貨時間: in store
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Product Description:

 

  Human Cell Expressed
  Animal-derived product free
  Endotoxin-free*
  Available in Bulk
  Higher Stability in Media
  10-Fold Higher Potency

HumanKine® GM-CSF is produced in a human cell expression system in serum-free, chemically defined media. It has a demonstrated greater stability under cell culture conditions making it ideal for efficient generation of Human Dendritic Cells. (See the preferred, time saving G4 protocol available at www.HumanZyme.com).

Technical Specifications:

 

  Species: Human
  Expression: Human Cell Expressed
  Activity: 0.4 to 2 ng/mL ED50
  Purity: >95%
  Endotoxin: Endotoxin-free*
  Molecular Mass: 15 to 36 kDa, monomer, glycosylated

Activity Assay:

The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

Purity Confirmation:

The protein was resolved by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.


*Endotoxin-free: <0.5 EU/µg

All HumanKine proteins are expressed in the HumaXpress® human cell expression system and have low endotoxin levels with native human post-translational modifications and folding.

[1]Mundkur L, Varma M, Shivanandan H, Krishna D, Kumar K, Lu X, Kakkar V. 2013. Activation of inflammatory cells and cytokines by peptide epiptopes in vitro: a simple in-vitro screening assay for prioritizing them for in-vivo studies. Inflammation Research. [PMID: 23400302]
[2]Smulski CR, Beyrath J, Decossas M, Chekkat N, Wlff P, Gionnet K, Guichard G, Speiser D, Schneider P, Fournel S. 2013. Cysteine-rich domain 1 of CD40 mediates receptor self-assembly. JBC [PMID:23463508]

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Stem cell reserch
HumanZyme develops and manufactures growth factors and cytokines for stem cell research applications. HumanKine® cytokines and growth factors are applied to stem cells for culture expansion or to drive differentiation into specific cell types. The human cell manufacturing system ensures native human glycosylation and other human-specific modifications that can result in better bioactivity and enhanced half-life.

Immunology Research
HumanZyme develops and manufactures cytokines and cell culture media for immunology applications. Cytokines are cell signaling molecules that enable cell-cell communication, stimulation, differentiation, and other processes. HumanKine® cytokines, expressed in human cells, possess authentic human glycosylation, folding, disulfide bonds, and other modifications which are important for biological activity, half-life, and human-specific functions.

Human Cellular Therapy
HumanKine® cytokines and growth factors originally developed for stem cell applications are beginning to be utilized by cellular therapy developers in early stage trials. Growth factors and cytokines are often employed ex vivo to drive stem cell differentiation into potentially therapeutic cells. For many growth factors and cytokines, the industry lacks cGMP proteins needed for late stage clinical trials and subsequent regulatory approval of promising cellular therapies. HumanKine proteins can be adapted to cGMP production.
 

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